Metabolism appears in lab without cells
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26-04-2014, 10:20 AM
Metabolism appears in lab without cells
http://www.newscientist.com/article/dn25...1uXPcdWjUp

Quote:Ralser's team took early ocean solutions and added substances known to be starting points for modern metabolic pathways, before heating the samples to between 50˚C and 70˚C – the sort of temperatures you might have found near a hydrothermal ventMovie Camera – for 5 hours. Ralser then analysed the solutions to see what molecules were present.

"In the beginning we had hoped to find one reaction or two maybe, but the results were amazing," says Ralser. "We could reconstruct two metabolic pathways almost entirely."

The pathways they detected were glycolysis and the pentose phosphate pathway, "reactions that form the core metabolic backbone of every living cell," Ralser adds. Together these pathways produce some of the most important materials in modern cells, including ATP – the molecule cells use to drive their machinery, the sugars that form DNA and RNA, and the molecules needed to make fats and proteins.

If these metabolic pathways were occurring in the early oceans, then the first cells could have enveloped them as they developed membranes.

In all, 29 metabolism-like chemical reactions were spotted, seemingly catalysed by iron and other metals that would have been found in early ocean sediments. The metabolic pathways aren't identical to modern ones; some of the chemicals made by intermediate steps weren't detected. However, "if you compare them side by side it is the same structure and many of the same molecules are formed," Ralser says. These pathways could have been refined and improved once enzymes evolved within cells.

We've got cell membranes, amino acids, RNA, and now primitive metabolism, all arising spontaneously without divine intervention. What was that about irreducible complexity?

E 2 = (mc 2)2 + (pc )2
614C → 714N + e + ̅νe
2 K(s) + 2 H2O(l) → 2 KOH(aq) + H2 (g) + 196 kJ/mol
It works, bitches.
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26-04-2014, 10:24 AM
RE: Metabolism appears in lab without cells
Now all people have to do is depopularize the idea that "life has to exist with water."
I hate whoever came up with that idea.

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26-04-2014, 11:06 AM
RE: Metabolism appears in lab without cells
It's pure guess word on my part, but i'm guessing the conditions we've given to life are born out of the ones we've seen on Earth, and as their the only benchmark we've got, they've been allocated to all life in the universe.
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26-04-2014, 12:14 PM
RE: Metabolism appears in lab without cells
(26-04-2014 11:06 AM)Dyer51 Wrote:  It's pure guess word on my part, but i'm guessing the conditions we've given to life are born out of the ones we've seen on Earth, and as their the only benchmark we've got, they've been allocated to all life in the universe.

I think it's more like, "We're positively sure life can exist with water, but we just don't want to make any false claims."

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26-04-2014, 12:33 PM
RE: Metabolism appears in lab without cells
(26-04-2014 10:20 AM)Phaedrus Wrote:  ...
We've got cell membranes, amino acids, RNA, and now primitive metabolism, all arising spontaneously without divine intervention. What was that about irreducible complexity?

Yabut...

I'm only going to be convinced when you sciencey types successfully identify the components that make up the soul.

You can't have life without that.

Dodgy

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26-04-2014, 12:51 PM
RE: Metabolism appears in lab without cells
(26-04-2014 12:33 PM)DLJ Wrote:  
(26-04-2014 10:20 AM)Phaedrus Wrote:  ...
We've got cell membranes, amino acids, RNA, and now primitive metabolism, all arising spontaneously without divine intervention. What was that about irreducible complexity?

Yabut...

I'm only going to be convinced when you sciencey types successfully identify the components that make up the soul.

You can't have life without that.

Dodgy

Where the hell is that irony font? Angry

Skepticism is not a position; it is an approach to claims.
Science is not a subject, but a method.
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26-04-2014, 12:52 PM
RE: Metabolism appears in lab without cells
(26-04-2014 10:20 AM)Phaedrus Wrote:  http://www.newscientist.com/article/dn25...1uXPcdWjUp

Quote:Ralser's team took early ocean solutions and added substances known to be starting points for modern metabolic pathways, before heating the samples to between 50˚C and 70˚C – the sort of temperatures you might have found near a hydrothermal ventMovie Camera – for 5 hours. Ralser then analysed the solutions to see what molecules were present.

"In the beginning we had hoped to find one reaction or two maybe, but the results were amazing," says Ralser. "We could reconstruct two metabolic pathways almost entirely."

The pathways they detected were glycolysis and the pentose phosphate pathway, "reactions that form the core metabolic backbone of every living cell," Ralser adds. Together these pathways produce some of the most important materials in modern cells, including ATP – the molecule cells use to drive their machinery, the sugars that form DNA and RNA, and the molecules needed to make fats and proteins.

If these metabolic pathways were occurring in the early oceans, then the first cells could have enveloped them as they developed membranes.

In all, 29 metabolism-like chemical reactions were spotted, seemingly catalysed by iron and other metals that would have been found in early ocean sediments. The metabolic pathways aren't identical to modern ones; some of the chemicals made by intermediate steps weren't detected. However, "if you compare them side by side it is the same structure and many of the same molecules are formed," Ralser says. These pathways could have been refined and improved once enzymes evolved within cells.

We've got cell membranes, amino acids, RNA, and now primitive metabolism, all arising spontaneously without divine intervention. What was that about irreducible complexity?

Makes the whole "abiogenesis is impossible" argument a whoooooole lot weaker.

Skepticism is not a position; it is an approach to claims.
Science is not a subject, but a method.
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26-04-2014, 01:12 PM
RE: Metabolism appears in lab without cells
It does seem that scientific opinion is swinging towards metabolisms self organising first followed by reproduction. Apparently conventional scientific opinion was that reproduction came first which doesn't make any sense to me.

Thanks for the link. It will prove very useful!
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27-04-2014, 12:22 PM
RE: Metabolism appears in lab without cells
(26-04-2014 12:51 PM)Chas Wrote:  
(26-04-2014 12:33 PM)DLJ Wrote:  Yabut...

I'm only going to be convinced when you sciencey types successfully identify the components that make up the soul.

You can't have life without that.

Dodgy

Where the hell is that irony font? Angry
Right by the sarcasm font.
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